The best choice depends on the skin concern and the formula your veterinarian recommends. DOUXO S3 PYO is best for owners seeking a shampoo with a stated 3% chlorhexidine concentration; Nizoral lists 2% chlorhexidine gluconate and 1% ketoconazole. Pet Honesty combines chlorhexidine and ketoconazole with aloe, while MiconaHex+Triz and Arava are additional medicated skin-care options whose supplied product details do not specify chlorhexidine. Check the label and ask a veterinarian which formula fits your dog.
| Product | Best suited for | Detail to compare |
|---|---|---|
| DOUXO S3 PYO | Dogs needing a stated 3% chlorhexidine shampoo | 6.7 fl oz; dogs and cats |
| Nizoral Ketoconazole Pet Shampoo | Owners comparing chlorhexidine and ketoconazole | 2% chlorhexidine gluconate; 1% ketoconazole |
| Pet Honesty Chlorhexidine Dog Shampoo | Itchy skin and odor concerns | Aloe; 16 oz |
| MiconaHex+Triz Shampoo | Multi-species fungal skin-care needs | Dogs, cats, and horses; unscented |
| Arava Medicated Dog Shampoo | Owners looking for a mineral-based wash | 28 Dead Sea minerals |
DOUXO S3 PYO 3% Chlorhexidine Shampoo

This 6.7-fluid-ounce shampoo is formulated with 3% chlorhexidine and described as an antiseptic cleanser for bacterial or yeast skin infections. The product information also says it hydrates skin and reports clinically proven results in as soon as seven days. It is listed for dogs and cats.
Best for: Pet owners seeking a clearly stated chlorhexidine concentration and a formula intended for bacterial or yeast-related skin concerns. It stands out among these options because its listed chlorhexidine percentage is explicit. Limitation: The bottle is smaller than the 16-ounce options in this list, and the product is described for specific skin concerns rather than routine grooming.
Nizoral Ketoconazole Pet Shampoo

Nizoral lists 1% ketoconazole and 2% chlorhexidine gluconate in a 16-ounce formula for dogs and cats. Its product description says the medicated shampoo supports antimicrobial skin care and helps reduce irritation, itching, and odor. The listed directions say to use it two to three times per week as needed or as directed by a veterinarian.
Best for: Owners comparing a combination of chlorhexidine gluconate and ketoconazole, particularly when odor or itching is part of the concern. Limitation: Follow the label or veterinary instructions for frequency; the product details do not establish that this schedule is appropriate for every dog.
Pet Honesty Chlorhexidine Itchy Skin Shampoo

Pet Honesty’s 16-ounce shampoo is marketed for dogs and cats with itchy or irritated skin. Its listed ingredients and features include chlorhexidine, ketoconazole, and soothing aloe. The product description also says the formula is made without sulfates, parabens, phthalates, alcohol, or artificial colors, and is intended to help with odor and hot spots.
Best for: Owners looking for a chlorhexidine-and-ketoconazole wash that also highlights aloe and a list of excluded additives. It is a larger bottle than DOUXO S3 PYO. Limitation: The supplied product details do not state the concentrations of its active ingredients, so compare its label with veterinary guidance.
MiconaHex+Triz Shampoo For Multiple Animals

MiconaHex+Triz is a 16-ounce, unscented shampoo listed for dogs, cats, and horses. Its product information says it supports healthy skin in animals with skin conditions and can help prevent and treat fungal skin concerns.
Best for: Households seeking one unscented skin-care shampoo for more than one listed animal species. It offers a fungal-care focus. Important distinction: The supplied features do not identify chlorhexidine or its concentration. Do not assume it is a chlorhexidine gluconate shampoo; verify the full ingredient label if that active ingredient is required.
Arava Medicated Dog Shampoo

Arava describes this dog shampoo as a deep cleanser made with 28 natural ingredients, including Dead Sea minerals. The product information says it cleanses the undercoat, supports a shiny coat, and is designed for dermatological concerns and irritated skin.
Best for: Owners considering a mineral-based medicated wash focused on cleansing and coat care. Important distinction: The supplied features do not state that the formula contains chlorhexidine gluconate. Choose it as a chlorhexidine shampoo only if the package label confirms that ingredient and it suits your veterinarian’s recommendation.
Buying Guide: How To Choose A Chlorhexidine Dog Shampoo
Does the label state chlorhexidine gluconate and its concentration?
Check the active ingredients rather than relying on a general “medicated” or “antibacterial” description. In this selection, DOUXO S3 PYO specifies 3% chlorhexidine, and Nizoral specifies 2% chlorhexidine gluconate. Pet Honesty lists chlorhexidine but the supplied details do not give a concentration. Ask your veterinarian whether a particular strength or combination is appropriate.
What skin concern are you addressing?
Products in this list describe support for issues such as itching, odor, fungal skin concerns, or bacterial and yeast-related skin problems. Those descriptions are not a diagnosis. Persistent itching, sores, spreading redness, or recurring odor can have different causes, so consult a veterinarian before choosing a medicated wash.
Which details matter for bathing?
Compare the listed animal species, bottle size, scent information, ingredients, and directions. MiconaHex+Triz is described as unscented and intended for dogs, cats, and horses. Nizoral provides a use-frequency statement, while other supplied details may not specify a bathing schedule. Follow the product label and veterinary instructions, and keep shampoo away from your dog’s eyes and mouth during bathing.
Frequently Asked Questions
What is chlorhexidine gluconate dog shampoo used for?
It is a medicated wash formulated with chlorhexidine gluconate. Product descriptions commonly position these shampoos for skin cleansing and related concerns, but a veterinarian should determine whether it is suitable for a particular dog.
Which shampoo in this list states its chlorhexidine strength?
DOUXO S3 PYO lists 3% chlorhexidine. Nizoral lists 2% chlorhexidine gluconate alongside 1% ketoconazole.
Can I use dog shampoo on my cat?
Use a product on cats only when its label specifically lists cats and a veterinarian confirms it is appropriate. Pet Honesty, Nizoral, DOUXO S3 PYO, and MiconaHex+Triz are described as suitable for cats in the supplied product information.
How often should I bathe my dog with medicated shampoo?
Follow the shampoo label and your veterinarian’s instructions. Nizoral’s listing says two to three times per week as needed or as directed by a veterinarian; that schedule should not be assumed for other products.