Medicated wipes offer a convenient way to address itching, hotspots, and skin infections at home. The products below are designed for dogs and cats and feature veterinary-strength actives, antifungal or antibacterial formulas, and soothing ingredients. Use as directed by a veterinarian to support skin health between baths or as part of a regular grooming routine.
| Product | Brand | Key Benefit |
|---|---|---|
| Nootie Medicated Wipes | Nootie | Chlorhexidine and Miconazole for skin infections and ear issues |
| Petazy 2% Chlorhexidine Wipes | Petazy | Medicated antifungal and antibacterial, large 5×6 inch pads |
| Douxo S3 Pyo Pads | Douxo | Chlorhexidine with Ophytrium for skin barrier support |
| Vetnique Dermabliss 3-in-1 Wipes | Vetnique | Three-in-one medicated wipes with antihistamine and hydrocortisone |
| HICC PET Itch Relief Wipes | HICC PET | Fast-acting itch relief with plant-based and soothing ingredients |
Note: Always verify suitability for your pet’s age, species, and skin condition with a veterinarian. These products vary in active ingredients and intended use, from antiseptic and antifungal to anti-itch and soothing formulas.
Nootie Medicated Wipes: 2% Chlorhexidine & 2% Miconazole

Nootie Medicated Wipes are formulated with 2% Chlorhexidine Gluconate and 2% Miconazole Nitrate, offering relief for skin infections and ear issues in dogs and cats. The XL 5″x6″ wipes cover more surface area, helping with hotspots, ringworm, dermatitis, and related infections. The formula emphasizes a paraben-, SLS-, and dye-free approach, making it suitable for sensitive skin when used as directed. Suitable for multi-purpose use, including ear infection management and facial areas where infections may occur.
Petazy 2% Chlorhexidine Wipes

Petazy offers XL 5×6 inch medicated wipes with a vet-strength antifungal and antibacterial formula designed to fight yeast, ringworm, hot spots, and skin infections. The wipes aim to soothe itching, redness, and odor while providing faster relief due to greater surface coverage per wipe. They are positioned as gentle enough for cats and dogs, making them a convenient option for broader skin concerns beyond routine cleaning.
Douxo S3 Pyo Pads

Douxo S3 Pyo Pads combine 3% Chlorhexidine with 0.5% Ophytrium to target bacterial and yeast skin infections. Marketed as non-prescription and veterinarian-recommended, these pads hydrate and disinfect while supporting the skin’s ecosystem. The inclusion of ophytrium helps bolster the skin barrier, promoting long-term resilience and reducing yeast counts within a week for many cases. Suitable for dogs and cats with inflammatory dermatological issues and infection signs.
Soothing Dog Paw Wipes by Chew + Heal Labs

These medicated paw wipes focus on itchy paws and irritations with a formula that includes chlorhexidine and ketoconazole. They are designed to reduce redness, moisture buildup, and excessive licking between toes and paw pads. They’re praised for being fast-absorbing and leaving no greasy residue, making them suitable for daily hygiene routines and quick relief after outdoor activities. The product emphasizes a skin-friendly approach for daily use on active dogs.
Smiling Paws Pets Antibacterial & Antifungal Wipes

Smiling Paws Pets wipes pair chlorhexidine with ketoconazole to tackle skin infections caused by bacteria, fungi, and yeast. They’re described as effective for hotspots, ringworm, mange, and pyoderma, making them a versatile option for both dogs and cats. The wipes are sized around 2.5”x2.5” to fit small crevices and accommodate use on paws, ears, and other sensitive areas. Aloe and fatty acids are included to aid soothing and skin conditioning.
Vetnique Dermabliss 3-in-1 Medicated Wipes

Dermabliss 3-in-1 wipes combine medicated antiseptic action with odor control and skin soothing. They target itching from allergies and skin irritations, offering a no-sting formula suitable for paw areas and sensitive skin. The wipes are designed for regular use to help manage itchy skin and related discomfort in dogs and cats, with a focus on providing a simple, vet-strength cleaning experience.
Vetnique Dermabliss Advanced Strength Wipes

These advanced-strength wipes feature 2% Chlorhexidine and 1% Ketoconazole to address common skin infections and irritations in dogs. Formulated to promote healthy skin, they combine antiseptic action with skin-supportive ingredients like lactic acid and aloe. The product aims to cleanse, exfoliate, deodorize, and soothe, offering a veterinary-strength option for ongoing skin care and infection management without harshness.
HICC PET Itch Relief Wipes

HICC PET offers a fast-relief wipe for itching and irritated skin, including hot spots and dry skin. The formula emphasizes hypoallergenic ingredients and plant-based components, with a triple oat complex and natural botanical elements. It provides immediate soothing action and aims to reduce scratching and licking, supporting wound prevention and healing while remaining gentle for daily use on dogs and cats.
Buying Guide: Key Purchase Considerations
- Active ingredients: Compare chlorhexidine, ketoconazole, miconazole, and hydrocortisone. Chlorhexidine helps with bacteria, while antifungal agents address yeast and ringworm. Hydrocortisone offers temporary itch relief but may not be suitable for all infections.
- Infection vs. irritation: Use antifungal/antibacterial formulas for infections; soothing or anti-itch formulations are better for non-infectious irritation and allergies.
- Surface area per wipe: Larger pads cover more skin per use, reducing the number of wipes needed for larger dogs. Smaller wipes fit paws or facial folds more easily.
- Species and age suitability: Ensure the product is appropriate for dogs and/or cats and check any age restrictions or veterinary recommendations.
- Skin sensitivity and fragrances: Look for hypoallergenic options free from harsh dyes or fragrances if your pet has sensitive skin or allergies.
- Frequency and duration: Some products are designed for daily use, others for temporary relief. Follow the label and consult a vet for a treatment plan.
- Veterinary trust and usage context: Vet-strength formulas may be more appropriate for persistent infections or severe itching, while routine care can rely on milder antiseptic wipes.
- Convenience and packaging: Consider pack size, availability, and whether wipes are pre-moistened or require a separate solution for use between baths.